The Team
Eric M. Thompson, MD
Dr. Eric Thompson is a Professor of Neurosurgery, Chief of the Division of Pediatric Neurosurgery, and Co-Directory of the Pediatric Brain Tumor Program at Washington University. Dr. Thompson received his Bachelor of Science degree from Duke University and his MD from the University of Nebraska College of Medicine prior to completing neurosurgery residency and a two year post doctoral fellowship in neuro-oncology at Oregon Health & Science University. He completed his pediatric neurosurgery fellowship at the Hospital for Sick Children in Toronto.
Jianyun Lu, PhD
Dr. Jianyun Lu is a Staff Scientist in the Thompson Lab. Dr. Lu received his Bachelor of Science and Master's of Science in chemistry at Zhongshan University in China. He completed his PhD in chemistry from the University of Georgia in Athens. He has more than eight years experience in cancer research, and his career goal is to discover and devlop innovative therapeutics to cure cancer.
Selected Publications
2024
TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M. Cell.
The safety and accuracy of intratumoral catheter placement to infuse viral immunotherapies in children with malignant brain tumors: a multi-institutional study.
Barkley A, Butler E, Park C, Friedman A, Landi D, Ashley DM, Bigner D, Bernstock JD, Friedman GK, Johnston JM*, Thompson EM*. Journal of Neurosurgery: Pediatrics. 2024; 33:359-366. Cover article.
Identification of genetic biomarkers to predict response to HSV-1 G207 and polio:rhinovirus immunotherapy.
Thompson EM, Kang KD, Stevenson K, Zhang H, Gromeier M, Ashley D, Brown M, Friedman GK. ITranslational Oncology. 2024; 40.
ABL1 and ABL2 regulate c-MYC-mediated medulloblastoma leptomeningeal dissemination.
Jones JK, Zhang H, Lyne AM, Cavalli FMG, Hassen WE, Stevenson K, Kornahrens R, Yang Y, Li S, Dell S, Reitman ZJ, Herndon JE 2nd, Hoj J, Pendergast AM, Thompson EM. Neuro-Oncology Advances. 2023; 5(1).
2023
Recombinant polio–rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial
Thompson EM, Landi D, Brown MC, Friedman H, McLendon R, Herndon, II JE, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM. The Lancet Child & Adolescent Health. 2023; 7(7):471-478.
CD155 is a putative therapeutic target in medulloblastoma
Li S, McLendon R, Sankey E, Kornaherns R, Lyne AM, Cavalli FMG, McKay Z, Herndon II JE, Remke M, Picard D, Gromeier M, Brown M, Thompson EM. Clinical and Translational Oncology. 2023; 25(3):696-705.
2022
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson A, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia J, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang E, Kumar S, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Bérubé P, Wang YC, Pfister SM, Delattre O, Kim SK, Bourdeaut F, Doz FP, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks P, Fèvre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng HK, Poon WS, Pollack IF, López-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Ferrucci V, De Antonellis P, Zollo M, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, de León FCP, Aguilar PE, Conti MPPD, Morrissy SA, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, RA Moore, Marra MA, Huang X, Reimand J, Sorensen PHB, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Golden JA, Ellison DW, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE, Suzuki H, Millen KJ, Taylor MD. Nature. 2022; 609(7929):1021-1028.
2021
The Transcriptional Landscape of Shh Medulloblastoma
Skowron P, Farooq H, Cavalli1 FMG, Morrissy AS, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Dai S, Stücklin AG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-Rabbo D, Bérubé P, Wang YC, Luu B, Suárez RA, Rastan A, Gillmor AH, Lee JJY, Zhang XY, Daniels C, Dirks P, Malkin D, Bouffet E, Tabori U, Loukides J, Doz FP, Bourdeaut F, Delattre OO, Masliah-Planchon J, Ayrault O, Kim SK, Meyronet D, Grajkowska WA, Carlotti CG, de Torres C, Mora J, Eberhart CG, Van Meir EG, Kumabe T, French PJ, Kros JM, Jabado N, Lach B, Pollack IF, Hamilton RL, Nageswara Rao AA, Giannini C, Olson JM, László B, Klekner A, Zitterbart K, Phillips JJ, Thompson RC, Cooper MK, Rubin JB, Liau LM, Garami M, Hauser P, Wai Li KK, Ng H, Poon WS, Gillespie GY, Chan JA, Jung S, McLendon RE, Thompson EM, Zagzag D, Vibhakar R, Ra RS, Garre ML, Schüller U, Shofuda T, Faria CC, López-Aguilar E, Zadeh G, Hui CC, Ramaswamy V, Bailey SD, Jones SJM, Mungal AJ, Moore RA, Calarco J, Stein L, Bader GD, Reimand J, Ragoussis J, Weiss WA, Marra MA, Suzuki H, Taylor MD. Nature Communications, 2021; 12(1):1749.
2020
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma
Tsvankin V, Hashizume R, Katagi H, Herndon JE, Lascola C, Venkatraman TN, Picard D, Burrus B, Becher OJ, Thompson EM. Neurosurgery, 2020; 86(5):742-751. PMID: 31225627.
2019
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD. Nature. 2019;572(7767):67-73. PMID: 31043743.
